53162-07-5

Upstream product

• 2700-22-3 Benzylidenemalononitrile 
• 105-39-5 chloroacetic acid ethyl ester 
• 64-17-5 ethanol 
• 341511-83-9 2-cyano-5-phenyl-3,5-dioxopentanonitrile 

Downstream Products

• 105576-84-9 5-Cyano-6-imino-1,4-diphenyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester 
• 39621-09-5 2,6-dihydroxy-4-phenyl-3-cyano-pyridine 
• 369654-33-1 ethyl 2-amino-3-cyano-4-phenylthiophene-5-carboxylate 
• 1180845-13-9 C₁₅H₁₄N₂O₂ 
• 1042683-09-9 C₂₀H₂₀N₂O₄ 
• 341512-01-4 5-cyano-6-imino-1-(4-methoxy-phenyl)-4-phenyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester 
• 341512-02-5 5-cyano-6-imino-4-phenyl-1-p-tolyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester 
• 105576-85-0 1-(4-Chloro-phenyl)-5-cyano-6-imino-4-phenyl-1,6-dihydro-pyridazine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Further studies on the reaction of ethyl benzoylacetate with malononitrile: Synthesis of some novel pyridine and pyridazine derivatives

2-Cyano-5-phenyl-3,5-dioxopentanonitrile undergoes alcoholysis followed by Knoevenagel condensation to afford ethyl 4,4-dicyano-3-phenyl-3-butenoate, a thermo dynamically controlled product, which undergoes cyclization in acid medium to afford 2,6-dihydroxy-4-phenylnicotinonitrile. Some azo derivatives of nicotinonitriles and of 2-aminopyran are described. 5-Arylazo-2-aminopyrans are transformed by acid treatment into pyridazine derivatives, whereas without the arylazo substituent pyridines are obtained.

Synthesis of some new heterocycles derived from arylmethylenemalononitriles

Arylmethylenemalononitriles 1 were treated with halo compounds under phase transfer catalysis (PTC) conditions to yield α-polyfunctional arylmethylene-malononitrile derivatives 2-4. The treatment of compounds 2-4 with hydrazine hydrate gave pyridinones 5,