methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate

Base Information

Chemical Name:methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate
CAS No.:1207203-68-6
Molecular Formula:C₂₁H₁₈ClFO₄S
Molecular Weight:420.889
Hs Code.:

Synonyms:methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate

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Chemical Property of methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate

Chemical Property:

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Technology Process of methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate

There total 8 articles about methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207203-61-9
methyl 5-(2-chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylate

: 1207203-68-6
methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate

Guidance literature:: With methanol; for 2h; Reflux;

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 1207203-68-6
methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -60 °C / Inert atmosphere

1.2: -60 - 0 °C

2.1: tetrahydrofuran / 3 h / Reflux

3.1: trichlorophosphate / dichloromethane / 45 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 60 °C

5.1: boron tribromide / dichloromethane / -50 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C

7.1: methanol / 2 h / Reflux

With methanol; sodium hexamethyldisilazane; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 85953-29-3
methyl 2-chloro-4-fluorobenzoate

: 1207203-68-6
methyl 5-(2-chloro-4-fluorophenyl)-4-[4-(3-hydroxypropoxy)phenyl]thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -60 °C / Inert atmosphere

1.2: -60 - 0 °C

2.1: tetrahydrofuran / 3 h / Reflux

3.1: trichlorophosphate / dichloromethane / 45 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 60 °C

5.1: boron tribromide / dichloromethane / -50 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C

7.1: methanol / 2 h / Reflux

With methanol; sodium hexamethyldisilazane; boron tribromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;