4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate

Base Information

• Chemical Name: 4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate
• CAS No.: 1429015-59-7
• Molecular Formula: C₂₂H₃₀NO₆P
• Molecular Weight: 435.457
• Mol file: 1429015-59-7.mol

Synonyms:4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate

Chemical Property of 4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate

There total 3 articles about 4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-(diethylamino)salicylaldehyde (195975-28-1) + O,O-diethyl 4-(bromomethyl)phenyl phosphate (916661-26-2) → 4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate (1429015-59-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.bmcl.2013.02.063

Reference yield:

O,O-diethyl 4-(hydroxymethyl)phenyl phosphate (223800-62-2) → 4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate (1429015-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C / Inert atmosphere; Schlenk technique

2: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere; Schlenk technique

With carbon tetrabromide; potassium carbonate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.02.063

Reference yield:

(4-hydroxyphenyl)methanol (623-05-2) → 4-((5-(diethylamino)-2-formylphenoxy)methyl)phenyl diethyl phosphate (1429015-59-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere; Schlenk technique

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 20 °C / Inert atmosphere; Schlenk technique

3: potassium carbonate / N,N-dimethyl-formamide / 60 °C / Inert atmosphere; Schlenk technique

With carbon tetrabromide; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.02.063

upstream raw materials:

O,O-diethyl 4-(hydroxymethyl)phenyl phosphate

(4-hydroxyphenyl)methanol

4-(diethylamino)salicylaldehyde

O,O-diethyl 4-(bromomethyl)phenyl phosphate

Downstream raw materials:

(E)-4-((2-(2-(benzo[d]thiazol-2-yl)-2-cyanovinyl)-5-(diethylamino)phenoxy)methyl)phenyl diethyl phosphate