3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole

Base Information

Chemical Name:3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole
CAS No.:701954-66-7
Molecular Formula:C₂₄H₃₃NO₇Si
Molecular Weight:475.614
Hs Code.:

Synonyms:3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole

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Chemical Property of 3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole

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Technology Process of 3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole

There total 3 articles about 3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 701954-62-3
3-(tert-butyldimethylsilanyloxy)-4-methoxybenzaldehyde oxime

: 701954-66-7
3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole

Guidance literature:: With sodium hypochlorite; triethylamine; In dichloromethane; water; Heating;
DOI:10.1016/j.bmc.2006.02.001

Reference yield:

: 97315-18-9
p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde

: 701954-66-7
3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / hydroxylamine hydrochloride; pyridine / methanol / 1 h / Heating

2: 10 percent / triethylamine; NaOCl / CH₂Cl₂; H₂O / Heating

With pyridine; sodium hypochlorite; hydroxylamine hydrochloride; triethylamine; In methanol; dichloromethane; water;
DOI:10.1016/j.bmc.2006.02.001

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 701954-66-7
3-[3-(tert-butyldimethylsilanyloxy)-4-methoxyphenyl]-5-(3,4,5-trimethoxyphenyl)-1,2,4-dioxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / DIEA / tetrahydrofuran / 24 h / 20 °C

2: 75 percent / NH₂OH*HCl; pyridine / ethanol / 1 h / Heating

3: 10 percent / Et₃N; NaOCl / H₂O; CH₂Cl₂ / 48 h / 0 - 20 °C

With pyridine; sodium hypochlorite; hydroxylamine hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.tetlet.2004.03.020