(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydronaphtho[1,2-b][1,4]thiazepin-3-yl acetate hydrochloride (1:1)

Base Information

Chemical Name:(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydronaphtho[1,2-b][1,4]thiazepin-3-yl acetate hydrochloride (1:1)
CAS No.:108383-96-6
Molecular Formula:C26H28 N2 O4 S . Cl H
Molecular Weight:501.0375
Hs Code.:

(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydronaphtho[1,2-b][1,4]thiazepin-3-yl acetate hydrochloride (1:1)

Synonyms:Naphtho[1,2-b][1,4]thiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-,monohydrochloride, (2S-cis)-; Ro 23-6152

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Chemical Property of (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydronaphtho[1,2-b][1,4]thiazepin-3-yl acetate hydrochloride (1:1)

Chemical Property:

Vapor Pressure:1.71E-17mmHg at 25°C
Boiling Point:663.9°Cat760mmHg
Flash Point:355.3°C
Density:g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydronaphtho[1,2-b][1,4]thiazepin-3-yl acetate hydrochloride (1:1)

There total 7 articles about (2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydronaphtho[1,2-b][1,4]thiazepin-3-yl acetate hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 108-24-7
acetic anhydride

: 108383-87-5
(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one

: 108383-96-6
(+)-cis-3-(acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-<2-(dimethylamino)ethyl>naphtho<1,2-b><1,4>thiazepin-4(5H)-one hydrochloride

Guidance literature:: With dmap; In dichloromethane;
DOI:10.1021/jo00029a013

Reference yield:

: 53338-20-8
2-aminonaphthalene-1-thiol

: 108383-96-6
(+)-cis-3-(acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-<2-(dimethylamino)ethyl>naphtho<1,2-b><1,4>thiazepin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 20 h / Heating

2: 94.5 percent / 2 N NaOH / ethanol / 1.) 4 h, reflux, 2.) RT, overnight

3: 85 percent / PTSA / xylene / 19 h / Heating

4: 88.6 percent / K₂CO₃ / H₂O; ethyl acetate / 16 h / Heating

5: 95 percent / DMAP / CH₂Cl₂

With dmap; sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; In ethanol; dichloromethane; water; ethyl acetate; toluene; xylene;
DOI:10.1021/jo00029a013

Reference yield:

: 125276-26-8
(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)naphtho[1,2-b][1,4]thiazepin-4(5H)-one

: 108383-96-6
(+)-cis-3-(acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-<2-(dimethylamino)ethyl>naphtho<1,2-b><1,4>thiazepin-4(5H)-one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 88.6 percent / K₂CO₃ / H₂O; ethyl acetate / 16 h / Heating

2: 95 percent / DMAP / CH₂Cl₂

With dmap; potassium carbonate; In dichloromethane; water; ethyl acetate;
DOI:10.1021/jo00029a013