(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one

Base Information

Chemical Name:(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one
CAS No.:108383-87-5
Molecular Formula:C₂₄H₂₆N₂O₃S
Molecular Weight:422.548
Hs Code.:

Synonyms:(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one

There total 6 articles about (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

: 4584-46-7
(2-chloroethyl)dimethylamine hydrochloride

: 125276-26-8
(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)naphtho[1,2-b][1,4]thiazepin-4(5H)-one

: 108383-87-5
(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one

Guidance literature:: With potassium carbonate; In water; ethyl acetate; for 16h; Heating;
DOI:10.1021/jo00029a013

Reference yield:

: 125276-26-8
(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)naphtho[1,2-b][1,4]thiazepin-4(5H)-one

: 107-99-3
2-(dimethylamino)ethyl chloride

: 108383-87-5
(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one

Guidance literature:: With potassium carbonate; In ethyl acetate;

Reference yield:

: 53338-20-8
2-aminonaphthalene-1-thiol

: 108383-87-5
(2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-5-[2-(dimethylamino)ethyl]naphtho[1,2-b][1,4]thiazepin-4(5H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 20 h / Heating

2: 94.5 percent / 2 N NaOH / ethanol / 1.) 4 h, reflux, 2.) RT, overnight

3: 85 percent / PTSA / xylene / 19 h / Heating

4: 88.6 percent / K₂CO₃ / H₂O; ethyl acetate / 16 h / Heating

With sodium hydroxide; potassium carbonate; toluene-4-sulfonic acid; In ethanol; water; ethyl acetate; toluene; xylene;
DOI:10.1021/jo00029a013