6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane

Base Information

Chemical Name:6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane
CAS No.:122213-36-9
Molecular Formula:C₃₈H₅₈O₄Si
Molecular Weight:606.962
Hs Code.:

Synonyms:6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane

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Chemical Property of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane

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Technology Process of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane

There total 12 articles about 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122213-35-8,122292-26-6
(E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one

: 122213-36-9
6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 ℃; for 2.5h;
DOI:10.1021/jo00275a019

Reference yield:

: 122213-32-5
(E)-(R)-7-Bromo-2,5-dimethyl-hept-3-ene

: 122213-36-9
6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / dimethylformamide / Ambient temperature

2: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) a) THF, -78 deg C, 50 min, b) 0 deg C, 30 min

3: oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

4: 74 mg / disodium hydrogen phosphate, Na/Hg / methanol / 2.5 h / 0 °C

With disodium hydrogenphosphate; sodium amalgam; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a019

Reference yield:

: 122213-31-4
(E)-(R)-3,6-Dimethyl-hept-4-en-1-ol

: 122213-36-9
6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<2-oxo-1(R),5(R),8-trimethylnon-6(E)-enyl>-2,2,5(S)-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) triethylamine, methanesulfonyl chloride, 2.) LiBr / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) acetone, reflux

2: 48 percent / dimethylformamide / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) a) THF, -78 deg C, 50 min, b) 0 deg C, 30 min

4: oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

5: 74 mg / disodium hydrogen phosphate, Na/Hg / methanol / 2.5 h / 0 °C

With disodium hydrogenphosphate; sodium amalgam; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; lithium bromide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a019