(E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one

Base Information

Chemical Name:(E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one
CAS No.:122213-35-8
Molecular Formula:C₄₄H₆₂O₆SSi
Molecular Weight:747.124
Hs Code.:

(E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one

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Chemical Property of (E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one

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Technology Process of (E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one

There total 11 articles about (E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122213-34-7,122292-27-7,122292-28-8,122292-29-9
(E)-(2S,6R)-4-Benzenesulfonyl-2-{(4R,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-ol

: 122213-35-8,122292-26-6
(E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1021/jo00275a019

Reference yield:

: 122213-32-5
(E)-(R)-7-Bromo-2,5-dimethyl-hept-3-ene

: 122213-35-8,122292-26-6
(E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / dimethylformamide / Ambient temperature

2: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) a) THF, -78 deg C, 50 min, b) 0 deg C, 30 min

3: oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a019

Reference yield:

: 122213-31-4
(E)-(R)-3,6-Dimethyl-hept-4-en-1-ol

: 122213-35-8,122292-26-6
(E)-(2R,6R)-4-Benzenesulfonyl-2-{(4S,5S,6R)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-6,9-dimethyl-dec-7-en-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) triethylamine, methanesulfonyl chloride, 2.) LiBr / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) acetone, reflux

2: 48 percent / dimethylformamide / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) a) THF, -78 deg C, 50 min, b) 0 deg C, 30 min

4: oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; lithium bromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a019