2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate

Base Information

• Chemical Name: 2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate
• CAS No.: 16352-91-3
• Molecular Formula: C₁₈H₁₂N₂O₆
• Molecular Weight: 352.303
• Mol file: 16352-91-3.mol

Synonyms:2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate

Chemical Property of 2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate

There total 2 articles about 2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

Salicyluric acid (487-54-7) + acetic anhydride (108-24-7) + 3-nitro-benzaldehyde (99-61-6) → 2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate (16352-91-3)

Guidance literature:

With sodium acetate; Reflux;

DOI:10.1134/S1070363219060161

Reference yield:

salicyloyl chloride (1441-87-8) → 2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate (16352-91-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 20 °C

2: sodium acetate / Reflux

With sodium acetate; sodium hydroxide; 2: |Erlenmeyer-Plochl-Bergmann;

DOI:10.1134/S1070363219060161

Reference yield: 76.0%

2-{4-[3-(nitrobenzylidene)-5-oxo-4,5-dihydrooxazol-2-yl]}phenyl acetate (16352-91-3) + aniline (62-53-3) → 2-[4-(3-nitrobenzylidene)-5-oxo-1-phenyl-4,5-dihydro-1H-imidazol-2-yl]phenyl acetate

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; Reflux;

DOI:10.1134/S1070363219060161

upstream raw materials:

Salicyluric acid

acetic anhydride

3-nitro-benzaldehyde

salicyloyl chloride