(E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime

Base Information

• Chemical Name: (E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime
• CAS No.: 1434602-38-6
• Molecular Formula: C₁₅H₁₃F₂NO
• Molecular Weight: 261.271
• Mol file: 1434602-38-6.mol

Synonyms:(E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime

Chemical Property of (E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime

There total 2 articles about (E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(E)-1-(3,4-difluorophenyl)ethan-1-one oxime (1434602-13-7) + benzyl bromide (100-39-0) → (E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime (1434602-38-6)

Guidance literature:

(E)-1-(3,4-difluorophenyl)ethan-1-one oxime; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/jo400371x

Reference yield:

3',4'-difluoroacetophenone (369-33-5) → (E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime (1434602-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / pH 5 / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

2.2: 18 h / 20 °C

With hydroxylamine hydrochloride; sodium hydride; sodium carbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jo400371x

Reference yield:

(E)-1-(3,4-difluorophenyl)ethanone O-benzyloxime (1434602-38-6) → (S)-1-(3,4-difluorophenyl)ethanamine (321318-17-6,276875-21-9,321318-15-4)

Guidance literature:

With borane-THF; C₁₉H₂₃BNO₃^(1-)*H⁽¹⁺⁾; In 1,4-dioxane; for 72h; enantioselective reaction; Inert atmosphere;

DOI:10.1021/jo400371x

upstream raw materials:

(E)-1-(3,4-difluorophenyl)ethan-1-one oxime

benzyl bromide

3',4'-difluoroacetophenone

Downstream raw materials:

(S)-1-(3,4-difluorophenyl)ethanamine

(S)-N-[1-(3,4-difluorophenyl)ethyl]acetamide

Refernces