(4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester

Base Information

Chemical Name:(4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester
CAS No.:341508-66-5
Molecular Formula:C₂₃H₃₅N₃O₆
Molecular Weight:449.547
Hs Code.:

Synonyms:(4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester

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Chemical Property of (4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester

Chemical Property:

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Technology Process of (4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester

There total 4 articles about (4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31972-52-8
Boc-Gly-Gly-OH

: (4S)-4-benzyl-6-aminohexanoic acid methyl ester hydrochloride

: 341508-66-5
(4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jo001308b

Reference yield:

: 341508-40-5
(S)-hexahydro-5-benzyl-2H-azepin-2-one

: 341508-66-5
(4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: HCl / H₂O / Heating

2: SOCl₂ / 0 - 20 °C

3: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; Et₃N / dimethylformamide / 20 °C

With hydrogenchloride; thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.1021/jo001308b

Reference yield:

: (S)-6-Amino-4-benzyl-hexanoic acid

: 341508-66-5
(4S)-4-benzyl-6-[N-(tert-butoxycarbonyl)-glycyl-glycyl]-aminohexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 0 - 20 °C

2: 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; Et₃N / dimethylformamide / 20 °C

With thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jo001308b