(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate

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Chemical Name:(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate
CAS No.:1345690-16-5
Molecular Formula:C₃₃H₄₁BrN₃O₁₀PS
Molecular Weight:782.646
Hs Code.:

Synonyms:(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate

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Chemical Property of (E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate

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Technology Process of (E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate

There total 9 articles about (E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1214876-55-7
1-(bromomethyl)-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indole-7-sulfonyl chloride

: 1345690-16-5
(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; potassium nitrate / 0.25 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -50 °C

3: methanol; caesium carbonate / dichloromethane; water / 0.25 h / -10 °C

4: EDCI*HBr; toluene-4-sulfonic acid / dichloromethane / 4 h

With methanol; sulfuric acid; EDCI*HBr; caesium carbonate; toluene-4-sulfonic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water;
DOI:10.1016/j.bmc.2011.08.045

Reference yield:

: 1214876-53-5
1-(1-(bromomethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone

: 1345690-16-5
(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 6 steps

1: chlorosulfonic acid / dichloromethane / 7 h / -78 - 5 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 °C

3: sulfuric acid; potassium nitrate / 0.25 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -50 °C

5: methanol; caesium carbonate / dichloromethane; water / 0.25 h / -10 °C

6: EDCI*HBr; toluene-4-sulfonic acid / dichloromethane / 4 h

With methanol; chlorosulfonic acid; oxalyl dichloride; sulfuric acid; EDCI*HBr; caesium carbonate; toluene-4-sulfonic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.045

Reference yield:

: 1214876-54-6
(7-(chlorosulfonyl)-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl methanesulfonate

: 1345690-16-5
(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1: lithium bromide / tetrahydrofuran / 96 h

2: sulfuric acid; potassium nitrate / 0.25 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -50 °C

4: methanol; caesium carbonate / dichloromethane; water / 0.25 h / -10 °C

5: EDCI*HBr; toluene-4-sulfonic acid / dichloromethane / 4 h

With methanol; sulfuric acid; EDCI*HBr; caesium carbonate; toluene-4-sulfonic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; lithium bromide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2011.08.045