(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate

Base Information

Chemical Name:(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate
CAS No.:1345690-12-1
Molecular Formula:C₂₅H₂₅BrN₃O₁₀PS
Molecular Weight:670.431
Hs Code.:

Synonyms:(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate

Suppliers and Price of (E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate

There total 10 articles about (E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1345690-16-5
(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl di-tert-butyl phosphate

: 1345690-12-1
(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 15h;
DOI:10.1016/j.bmc.2011.08.045

Reference yield:

: 1214876-53-5
1-(1-(bromomethyl)-1H-benzo[e]indol-3(2H)-yl)-2,2,2-trifluoroethanone

: 1345690-12-1
(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 7 steps

1: chlorosulfonic acid / dichloromethane / 7 h / -78 - 5 °C

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 1 h / 0 °C

3: sulfuric acid; potassium nitrate / 0.25 h / 0 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -50 °C

5: methanol; caesium carbonate / dichloromethane; water / 0.25 h / -10 °C

6: EDCI*HBr; toluene-4-sulfonic acid / dichloromethane / 4 h

7: trifluoroacetic acid / dichloromethane / 15 h

With methanol; chlorosulfonic acid; oxalyl dichloride; sulfuric acid; EDCI*HBr; caesium carbonate; toluene-4-sulfonic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.08.045

Reference yield:

: 1214876-55-7
1-(bromomethyl)-3-(2,2,2-trifluoroacetyl)-2,3-dihydro-1H-benzo[e]indole-7-sulfonyl chloride

: 1345690-12-1
(E)-2-(1-(bromomethyl)-3-(3-(4-methoxyphenyl)acryloyl)-5-nitro-2,3-dihydro-1H-benzo[e]indole-7-sulfonamido)ethyl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; potassium nitrate / 0.25 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / -50 °C

3: methanol; caesium carbonate / dichloromethane; water / 0.25 h / -10 °C

4: EDCI*HBr; toluene-4-sulfonic acid / dichloromethane / 4 h

5: trifluoroacetic acid / dichloromethane / 15 h

With methanol; sulfuric acid; EDCI*HBr; caesium carbonate; toluene-4-sulfonic acid; potassium nitrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water;
DOI:10.1016/j.bmc.2011.08.045