(Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

Base Information

Chemical Name:(Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime
CAS No.:1393657-02-7
Molecular Formula:C₁₂H₁₈FNOSi
Molecular Weight:239.365
Hs Code.:

Synonyms:(Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

Suppliers and Price of (Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

Chemical Property:

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Technology Process of (Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

There total 1 articles about (Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1393657-00-5
6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone

: 593-56-6
N-methoxylamine hydrochloride

: 1393657-02-7
(Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

: 1393657-03-8
(E)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

Guidance literature:: With pyridine; at 20 ℃; for 18.5h; Overall yield = 81 %; Optical yield = 33.333 %de; Inert atmosphere;
DOI:10.1021/jm300648b

Reference yield:

: 109-04-6
2-bromo-pyridine

: 1393657-02-7
(Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

: 1393657-06-1
(Z)-6-fluoro-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-methyl oxime

Guidance literature:: (Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime; With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

2-bromo-pyridine; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;
DOI:10.1021/jm300648b

Reference yield:

: 5315-25-3
2-bromo-6-methylpyridine

: 1393657-02-7
(Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime

: 1393657-07-2
(Z)-6-fluoro-3-((6-methylpyridin-2-yl)ethynyl)cyclohex-2-enone O-methyl oxime

Guidance literature:: (Z)-6-fluoro-3-((trimethylsilyl)ethynyl)cyclohex-2-enone O-methyl oxime; With tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

2-bromo-6-methylpyridine; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 21h; Inert atmosphere;
DOI:10.1021/jm300648b