ethyl 6-(hydroxymethyl)-4-((4-(trifluoromethyl)phenyl)ethynyl)pyridin-2-yl(phenyl)phosphinate

Base Information

Chemical Name:ethyl 6-(hydroxymethyl)-4-((4-(trifluoromethyl)phenyl)ethynyl)pyridin-2-yl(phenyl)phosphinate
CAS No.:1421932-27-5
Molecular Formula:C₂₃H₁₉F₃NO₃P
Molecular Weight:445.378
Hs Code.:

Synonyms:ethyl 6-(hydroxymethyl)-4-((4-(trifluoromethyl)phenyl)ethynyl)pyridin-2-yl(phenyl)phosphinate

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Chemical Property of ethyl 6-(hydroxymethyl)-4-((4-(trifluoromethyl)phenyl)ethynyl)pyridin-2-yl(phenyl)phosphinate

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Technology Process of ethyl 6-(hydroxymethyl)-4-((4-(trifluoromethyl)phenyl)ethynyl)pyridin-2-yl(phenyl)phosphinate

There total 2 articles about ethyl 6-(hydroxymethyl)-4-((4-(trifluoromethyl)phenyl)ethynyl)pyridin-2-yl(phenyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1431328-87-8
ethyl [4-bromo-6-(hydroxymethyl)pyridine-2-yl](phenyl)phosphinate

: 40230-95-3
1-(4-trifluoromethylphenyl)-2-trimethylsilylethyne

: 1421932-27-5
ethyl 6-(hydroxymethyl)-4-((4-(trifluoromethyl)phenyl)ethynyl)pyridin-2-yl(phenyl)phosphinate

Guidance literature:: With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In tetrahydrofuran; at 65 ℃; for 15h; Inert atmosphere;
DOI:10.1039/c2cc35247h

Reference yield: 62.0%

: 705-31-7
4-trifluoromethylphenylacetylene

: 1431328-87-8
ethyl [4-bromo-6-(hydroxymethyl)pyridine-2-yl](phenyl)phosphinate

: 1421932-27-5
ethyl 6-(hydroxymethyl)-4-((4-(trifluoromethyl)phenyl)ethynyl)pyridin-2-yl(phenyl)phosphinate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine; In tetrahydrofuran;
DOI:10.1002/chem.201402415