tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate
• CAS No.: 1534377-96-2
• Molecular Formula: C₂₁H₃₂BFN₂O₄
• Molecular Weight: 406.305
• Mol file: 1534377-96-2.mol

Synonyms:tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate

There total 1 articles about tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-(2-fluorophenyl)piperazine-1-carboxylate + bis(pinacol)diborane (73183-34-3) → tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate (1534377-96-2) + C21H32BFN2O4

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; C₂₉H₃₁N₃; In 1,4-dioxane; at 80 ℃; for 65h; Overall yield = 57percent; Overall yield = 59 percentSpectr.; regioselective reaction;

DOI:10.1021/acscatal.1c01206

Reference yield: 55.0%

tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate (1534377-96-2) + 4-[2-(4-chloro-1,6-dimethyl-pyrrolo[3,2-c]pyridin-2-yl)ethyl]morpholine → tert-butyl 4-[4-[1,6-dimethyl-2-(2-morpholinoethyl)pyrrolo[3,2-c]pyridin-4-yl]-2-fluorophenyl]piperazine-1-carboxylate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 95 ℃; for 16.25h; Inert atmosphere;

Reference yield:

tert-butyl 4-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate (1534377-96-2) → C15H20F(18)FN2O2

Guidance literature:

With 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo[8.8.8]hexacosan/[18F]fluoride; tetrakis(pyridine)copper(II) bis(trifluoromethanesulfonate); In N,N-dimethyl acetamide; at 110 ℃; for 0.333333h;

DOI:10.1039/d0ra04943c

upstream raw materials:

bis(pinacol)diborane