3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

Base Information

Chemical Name:3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole
CAS No.:1418297-03-6
Molecular Formula:C₁₆H₁₄F₄N₂
Molecular Weight:310.294
Hs Code.:

Synonyms:3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

Suppliers and Price of 3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

There total 9 articles about 3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 7647-01-0,15364-23-5
hydrogenchloride

: 1418296-87-3
2-({fluoro[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]methyl}sulphonyl)-1,3-benzothiazole

: 1418297-04-7
4-[1-(trifluoromethyl)cyclopropyl]benzaldehyde

: 1418297-03-6
3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

Guidance literature:: 2-({fluoro[5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl]methyl}sulphonyl)-1,3-benzothiazole; 4-[1-(trifluoromethyl)cyclopropyl]benzaldehyde;

hydrogenchloride; In 1,4-dioxane; at 20 ℃; Reagent/catalyst; Temperature; Time; Solvent;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418297-03-6
3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.2: 20 °C

With toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418297-03-6
3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.2: 20 °C

With triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;