1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine

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Chemical Name:1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine
CAS No.:1418296-66-8
Molecular Formula:C₂₉H₃₁F₄N₅
Molecular Weight:525.592
Hs Code.:

Synonyms:1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine

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Chemical Property of 1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine

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Technology Process of 1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine

There total 14 articles about 1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1418297-03-6
3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazole

: 1227160-33-9
1-[4-(chloromethyl)pyridin-2-yl]-4-cyclopropylpiperazine

: 1418296-66-8
1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 18h; Reflux;

Reference yield:

: 4027-57-0
ethyl 5-methyl-1H-pyrazole-3-carboxylate

: 1418296-66-8
1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

2.2: 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

4.1: N,N-dimethyl-formamide / 1 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

6.2: 16 h / -78 - 20 °C

7.2: 20 °C

8.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C / Reflux

With potassium tert-butylate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1418296-88-4
ethyl 5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carboxylate

: 1418296-66-8
1-cyclopropyl-4-[4-({3-[(Z)-1-fluoro-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}vinyl]-5-methyl-1H-pyrazol-1-yl}methyl)pyridin-2-yl]piperazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 17 h / 0 - 20 °C

1.2: 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 2 h / 0 °C

3.1: N,N-dimethyl-formamide / 1 h / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran; toluene; hexane / 0.5 h / -78 °C

5.2: 16 h / -78 - 20 °C

6.2: 20 °C

7.1: potassium tert-butylate / tetrahydrofuran / 18 h / 20 °C / Reflux

With potassium tert-butylate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;