1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide

Base Information

Chemical Name:1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide
CAS No.:133053-61-9
Molecular Formula:C₁₅H₁₅N₃O₂
Molecular Weight:269.303
Hs Code.:

Synonyms:1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide

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Chemical Property of 1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide

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Technology Process of 1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide

There total 3 articles about 1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.1%

: 13610-02-1
1-phenoxy-2-propyne

: 133053-60-8
5-iodo-1,3-dimethyl-1H-pyrazole-4-carboxamide

: 133053-61-9
1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide

Guidance literature:: With copper(l) iodide; diethylamine; bis-triphenylphosphine-palladium(II) chloride; at 50 - 55 ℃; for 13h;
DOI:10.1007/BF00958258

Reference yield:

: 124845-21-2
1,3-dimethyl-1H-pyrazole-4-carboxamide

: 133053-61-9
1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 81.5 percent / I₂, HIO₃, 30percent H₂SO₄ / acetic acid / 6 h / 80 °C

2: 75.1 percent / CuI, Et₂NH / Pd(PPh₃)2Cl₂ / 13 h / 50 - 55 °C

With copper(l) iodide; sulfuric acid; iodine; iodic acid; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetic acid;
DOI:10.1007/BF00958258

Reference yield:

: 78703-53-4
1,3-dimethyl-1H-pyrazole-4-carboxylic acid

: 133053-61-9
1,3-Dimethyl-5-(3-phenoxyprop-1-ynyl)pyrazole-4-carbonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) SOCl₂, 2.) NH₃ / 1.) reflux, 2.) CHCl₃, dioxane

2: 81.5 percent / I₂, HIO₃, 30percent H₂SO₄ / acetic acid / 6 h / 80 °C

3: 75.1 percent / CuI, Et₂NH / Pd(PPh₃)2Cl₂ / 13 h / 50 - 55 °C

With copper(l) iodide; thionyl chloride; sulfuric acid; ammonia; iodine; iodic acid; diethylamine; bis-triphenylphosphine-palladium(II) chloride; In acetic acid;
DOI:10.1007/BF00958258