(Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine

Base Information

• Chemical Name: (Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine
• CAS No.: 180072-66-6
• Molecular Formula: C₁₆H₂₉NSi₂
• Molecular Weight: 291.584
• Mol file: 180072-66-6.mol

Synonyms:(Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine

Chemical Property of (Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine

There total 1 articles about (Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-phenyl-propionaldehyde (104-53-0) + bis(trimethylsilyl)methylamine (134340-00-4) → (Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine (180072-66-6)

Guidance literature:

With MS 4A; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/chem.19970030909

Reference yield:

(Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine (180072-66-6) → [(3S,4R)-1-(Bis-trimethylsilanyl-methyl)-2-oxo-4-phenethyl-azetidin-3-yl]-carbamic acid tert-butyl ester (198021-56-6)

Guidance literature:

Multi-step reaction with 3 steps

1: NEt₃, MS 4A / CHCl₃ / 20 h / Heating

2: Li, NH₃ / tetrahydrofuran; 2-methyl-propan-2-ol / 0.05 h / -78 °C

3: CH₂Cl₂ / 3 h / Ambient temperature

With ammonia; lithium; triethylamine; In tetrahydrofuran; dichloromethane; chloroform; tert-butyl alcohol;

DOI:10.1002/chem.19970030909

Reference yield:

(Bis-trimethylsilanyl-methyl)-[3-phenyl-prop-(E)-ylidene]-amine (180072-66-6) → (3S,4R)-3-Amino-1-(bis-trimethylsilanyl-methyl)-4-phenethyl-azetidin-2-one

Guidance literature:

Multi-step reaction with 2 steps

1: NEt₃, MS 4A / CHCl₃ / 20 h / Heating

2: Li, NH₃ / tetrahydrofuran; 2-methyl-propan-2-ol / 0.05 h / -78 °C

With ammonia; lithium; triethylamine; In tetrahydrofuran; chloroform; tert-butyl alcohol;

DOI:10.1002/chem.19970030909

upstream raw materials:

3-phenyl-propionaldehyde

bis(trimethylsilyl)methylamine

Downstream raw materials:

(S)-3-[(3S,4R)-1-(Bis-trimethylsilanyl-methyl)-2-oxo-4-phenethyl-azetidin-3-yl]-4-phenyl-oxazolidin-2-one

(4S,5R)-3-[(3S,4R)-1-(Bis-trimethylsilanyl-methyl)-2-oxo-4-phenethyl-azetidin-3-yl]-4,5-diphenyl-oxazolidin-2-one

[(3S,4R)-1-(Bis-trimethylsilanyl-methyl)-2-oxo-4-phenethyl-azetidin-3-yl]-carbamic acid tert-butyl ester

((3S,4R)-2-Oxo-4-phenethyl-azetidin-3-yl)-carbamic acid tert-butyl ester