(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one

Base Information

Chemical Name:(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one
CAS No.:184716-95-8
Molecular Formula:C₂₁H₂₀N₂O₄
Molecular Weight:364.401
Hs Code.:

Synonyms:(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one

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Chemical Property of (S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one

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Technology Process of (S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one

There total 13 articles about (S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027933-53-4
(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one

: 184716-95-8
(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one

Guidance literature:: With (Cl₃CO)2CO; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; Yield given;
DOI:10.1021/jo9612180

Reference yield:

: (S)-3-[(2S,3S)-1-Benzyl-2-((S)-1-hydroxy-ethyl)-4-oxo-azetidin-3-yl]-4-phenyl-oxazolidin-2-one

: 184716-95-8
(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one

Guidance literature:: With (Cl₃CO)2CO; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; Yield given;
DOI:10.1021/jo9612180

Reference yield:

: 99333-55-8
2-(4(S)-phenyloxazolidin-2-on-3-yl)acetyl chloride

: 184716-95-8
(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) toluene, 0 deg C, 2 h; room temperature, overnight

2: n-Bu₄NF / tetrahydrofuran

3: (Cl₃CO)2CO, DMSO, NEt₃ / CH₂Cl₂ / -78 °C

With (Cl₃CO)2CO; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9612180