(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one

Base Information

Chemical Name:(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one
CAS No.:1027933-53-4
Molecular Formula:C₁₉H₂₄N₂O₄
Molecular Weight:344.411
Hs Code.:

Synonyms:(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one

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Chemical Property of (S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one

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Technology Process of (S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one

There total 5 articles about (S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1053253-08-9
(S)-3-[(2S,3S)-1-Benzyl-2-((S)-1-hydroxy-ethyl)-4-oxo-azetidin-3-yl]-4-tert-butyl-oxazolidin-2-one

: 1027933-53-4
(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one

Guidance literature:: With (Cl₃CO)2CO; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 ℃; Yield given;
DOI:10.1021/jo9612180

Reference yield:

: 54705-42-9
(S)-4-tert-butyloxazolidin-2-one

: 1027933-53-4
(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH, 2.) NaOH / 1.) THF, 0 deg C, 2 h, 2.) H₂O, THF, room temperature, 2 h

2: (COCl)2, DMF / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) toluene, 0 deg C, 2 h; room temperature, overnight

4: n-Bu₄NF / tetrahydrofuran

5: (Cl₃CO)2CO, DMSO, NEt₃ / CH₂Cl₂ / -78 °C

With sodium hydroxide; oxalyl dichloride; (Cl₃CO)2CO; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9612180

Reference yield:

: 184717-19-9
(S)-2-(4-tert-butyl-2-oxo-1,3-oxazolidin-3-yl)acetic acid

: 1027933-53-4
(S)-3-((2S,3S)-2-Acetyl-1-benzyl-4-oxo-azetidin-3-yl)-4-tert-butyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2, DMF / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) toluene, 0 deg C, 2 h; room temperature, overnight

3: n-Bu₄NF / tetrahydrofuran

4: (Cl₃CO)2CO, DMSO, NEt₃ / CH₂Cl₂ / -78 °C

With oxalyl dichloride; (Cl₃CO)2CO; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9612180