3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole
CAS No.:1312793-97-7
Molecular Formula:C₂₀H₂₇N₃O₅S
Molecular Weight:421.517
Hs Code.:

Synonyms:3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole

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Chemical Property of 3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole

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Technology Process of 3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole

There total 5 articles about 3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3-(3-cyclopentyloxy-4-methoxyphenyl)-5-(piperidin-4-yl)-1,2,4-oxadiazole

: 124-63-0
methanesulfonyl chloride

: 1312793-97-7
3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 30 ℃; for 5h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.031

Reference yield:

: 1163716-03-7
tert-butyl 4-(3-(3-cyclopentyloxy-4-methoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

: 1312793-97-7
3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

2: triethylamine / dichloromethane / 5 h / 0 - 30 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1111/j.1747-0285.2011.01304.x

Reference yield:

: 874485-04-8
C₁₃H₁₈N₂O₃

: 1312793-97-7
3-(3-cyclopentyloxy-4-methoxy-phenyl)-5-(1-methylsulfonylpiperidin-4-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

1.2: 13.5 h / 0 - 110 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 25 °C

3.1: triethylamine / dichloromethane / 5 h / 0 - 30 °C / Inert atmosphere

With triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1111/j.1747-0285.2011.01304.x