4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline

Base Information

Chemical Name:4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline
CAS No.:1613696-57-3
Molecular Formula:C₁₈H₂₄N₄O₄
Molecular Weight:360.413
Hs Code.:

Synonyms:4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline

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Chemical Property of 4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline

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Technology Process of 4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline

There total 3 articles about 4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 50998-05-5
N-(2-aminopropyl)morpholine

: 1428368-75-5
4-(4-fluoro-3-nitrophenyl)-3,5-dimethyl-1,2-oxazole

: 1613696-57-3
4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 80 ℃; for 16h;
DOI:10.1021/ja412434f

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1613696-57-3
4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline

Guidance literature:: Multi-step reaction with 2 steps

1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 80 °C

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; 1: |Suzuki Coupling;
DOI:10.1021/ja412434f

Reference yield:

: 832114-00-8
3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole

: 1613696-57-3
4-(3,5-dimethyl-1,2-oxazol-4-yl)-N-[1-(morpholin-4-yl)propan-2-yl]-2-nitroaniline

Guidance literature:: Multi-step reaction with 2 steps

1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 80 °C

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; 1: |Suzuki Coupling;
DOI:10.1021/ja412434f