7-methyl-2,7-diazaspiro[4.5]decane dihydrochloride

Base Information

• Chemical Name: 7-methyl-2,7-diazaspiro[4.5]decane dihydrochloride
• CAS No.: 1086395-12-1
• Molecular Formula: C₉H₁₈N₂
• Molecular Weight: 154.255
• Hs Code.: 2933998090
• Mol file: 1086395-12-1.mol

Synonyms:7-methyl-2,7-diazaspiro[4.5]decane

Chemical Property of 7-methyl-2,7-diazaspiro[4.5]decane dihydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

7-Methyl-2,7-diazaspiro[4.5]decane ^*data from reagent suppliers

Safty Information:

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Technology Process of 7-methyl-2,7-diazaspiro[4.5]decane dihydrochloride

There total 9 articles about 7-methyl-2,7-diazaspiro[4.5]decane dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

7-methyl-2,7-diazaspiro[4.5]decane-3,6,8-trione (1433194-55-8) → 7-methyl-2,7-diazaspiro[4.5]decane (1086395-12-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2013.03.064

Reference yield:

Dimethyl 1-cyanoethane-1,2-dicarboxylate (6283-71-2) → 7-methyl-2,7-diazaspiro[4.5]decane (1086395-12-1)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine / water / 3.75 h / 0 - 20 °C

2: platinum(IV) oxide / ethanol / 48 h / 6080.41 Torr / Autoclave

3: hydrogenchloride / water / 2 h / Reflux

4: water; methanol

5: toluene-4-sulfonic acid / para-xylene / Reflux

6: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

With hydrogenchloride; platinum(IV) oxide; lithium aluminium tetrahydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; para-xylene; water;

DOI:10.1016/j.tet.2013.03.064

Reference yield:

4-O-tert-butyl 1-O,2-O-dimethyl 2-cyanobutane-1,2,4-tricarboxylate (1433194-49-0) → 7-methyl-2,7-diazaspiro[4.5]decane (1086395-12-1)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 72 h / 6080.41 Torr / Autoclave

2: hydrogenchloride / water / 2 h / Reflux

3: water / 20 - 180 °C

4: toluene-4-sulfonic acid / para-xylene / Reflux

5: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux

With hydrogenchloride; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; para-xylene; water;

DOI:10.1016/j.tet.2013.03.064

upstream raw materials:

Dimethyl 1-cyanoethane-1,2-dicarboxylate

4-O-tert-butyl 1-O,2-O-dimethyl 2-cyanobutane-1,2,4-tricarboxylate

1-tert-butyl 3-ethyl 4-methyl 3-cyano-1,3,4-butanetricarboxylate

C₁₄H₂₃NO₅

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