4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol

Base Information

• Chemical Name: 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol
• CAS No.: 135426-15-2
• Molecular Formula: C₂₈H₂₆FNO
• Molecular Weight: 411.519

Synonyms:4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol

Chemical Property of 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol

Chemical Property:

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Technology Process of 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol

There total 5 articles about 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinecarboxylic acid, ethyl ester → 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol (135426-15-2)

Guidance literature:

With sodium hydroxide; LiAlH₄; In water;

Reference yield:

1-(2-(phenylmethyl)phenyl)ethanone (61608-94-4) → 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol (135426-15-2)

Guidance literature:

Multi-step reaction with 4 steps

1: EtONa / ethanol / 16 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; ammonium acetate; sodium ethanolate; In tetrahydrofuran; ethanol; acetic acid;

DOI:10.1021/jm00113a019

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinemethanol (135426-15-2)

Guidance literature:

Multi-step reaction with 4 steps

1: EtONa / ethanol / 16 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; ammonium acetate; sodium ethanolate; In tetrahydrofuran; ethanol; acetic acid;

DOI:10.1021/jm00113a019

upstream raw materials:

1-(2-(phenylmethyl)phenyl)ethanone

4-fluorobenzaldehyde

Downstream raw materials:

(S)-4-[[[4-(4-Fluorophenyl)-2-(1-methylethyl)-6-[2-(phenylmethyl)phenyl]-3-pyridinyl]ethynyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, disodium salt

6-(2-Benzyl-phenyl)-3-(2,2-dibromo-vinyl)-4-(4-fluoro-phenyl)-2-isopropyl-pyridine

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