tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate

Base Information

Chemical Name:tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate
CAS No.:1104196-45-3
Molecular Formula:C₂₅H₄₂N₂O₇
Molecular Weight:482.618
Hs Code.:

Synonyms:tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate

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Chemical Property of tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate

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Technology Process of tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate

There total 3 articles about tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.2%

: 14140-15-9
4-(2-bromoethyl)phenol

: 231304-42-0
1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecane-7-carboxylic acid tert-butyl ester

: 1104196-45-3
tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 - 65 ℃; for 25h; Inert atmosphere;
DOI:10.1002/chem.201202925

Reference yield:

: 23978-55-4
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane

: 1104196-45-3
tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-dioxane / 26 h / 20 - 40 °C

2: caesium carbonate / acetonitrile / 25 h / 20 - 65 °C / Inert atmosphere

With caesium carbonate; In 1,4-dioxane; acetonitrile;
DOI:10.1002/chem.201202925

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1104196-45-3
tert-butyl 16-(4-hydroxyphenethyl)-1,4,10,13-tetraoxa-7,16-diazacyclooctadecane-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-dioxane / 26 h / 20 - 40 °C

2: caesium carbonate / acetonitrile / 25 h / 20 - 65 °C / Inert atmosphere

With caesium carbonate; In 1,4-dioxane; acetonitrile;
DOI:10.1002/chem.201202925