tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate

Base Information

Chemical Name:tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate
CAS No.:1456507-48-4
Molecular Formula:C₁₉H₂₅N₃O₃
Molecular Weight:343.426
Hs Code.:

Synonyms:tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate

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Chemical Property of tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate

Chemical Property:

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Technology Process of tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate

There total 4 articles about tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53292-90-3,130309-46-5,53292-89-0
trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid

: 613-94-5
benzoic acid hydrazide

: 1456507-48-4
tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate

Guidance literature:: trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid; benzoic acid hydrazide; With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20 ℃; for 23h;

With N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; In acetonitrile; at 20 ℃; for 23h; Inert atmosphere;

Reference yield:

: 1507362-14-2
C₁₉H₂₇N₃O₄

: 1456507-48-4
tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm401317z

Reference yield:

: 613-94-5
benzoic acid hydrazide

: 1456507-48-4
tert-butyl ((1r,4r)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / acetonitrile / 19 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride / acetonitrile / 24 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In acetonitrile;
DOI:10.1021/jm401317z