Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester

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Chemical Name:Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester
CAS No.:306739-89-9
Molecular Formula:C₂₆H₄₃NO₅S
Molecular Weight:481.697
Hs Code.:

Synonyms:Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester

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Chemical Property of Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester

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Technology Process of Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester

There total 3 articles about Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124-63-0
methanesulfonyl chloride

: 306739-78-6
(4S,5S)-5-(4-hydroxybutyl)-4-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 306739-89-9
Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1021/jo0005621

Reference yield:

: 306739-88-8
(4S,5S)-5-but-3-enyl-4-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 306739-89-9
Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: disialylborane / tetrahydrofuran / 5 h / 20 °C

1.2: 75 percent / aq. NaOH; aq. H₂O₂ / H₂O / 2 h / 20 °C

2.1: 0.701 g / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

With disialylborane; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: hydroboration / 1.2: Oxidation / 2.1: mesylation;
DOI:10.1021/jo0005621

Reference yield:

: 306739-76-4
(4S,5S)-5-but-3-enyl-3,3-dichloro-4-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 306739-89-9
Methanesulfonic acid 4-{(2S,3S)-5-oxo-3-[(R)-1-(2,4,6-triisopropyl-phenyl)-ethoxy]-pyrrolidin-2-yl}-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3.16 g / NH₄Cl; Zmn-Cu / methanol

2.1: disialylborane / tetrahydrofuran / 5 h / 20 °C

2.2: 75 percent / aq. NaOH; aq. H₂O₂ / H₂O / 2 h / 20 °C

3.1: 0.701 g / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

With disialylborane; copper; ammonium chloride; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane; 1.1: Dehalogenation / 2.1: hydroboration / 2.2: Oxidation / 3.1: mesylation;
DOI:10.1021/jo0005621