5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol

Base Information

Chemical Name:5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol
CAS No.:251317-73-4
Molecular Formula:C₂₁H₃₅NO₅
Molecular Weight:381.513
Hs Code.:

Synonyms:5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol

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Chemical Property of 5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol

Chemical Property:

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Technology Process of 5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol

There total 3 articles about 5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 251317-72-3
5-amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol

: 251317-73-4
5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/S0968-0896(99)00104-2

Reference yield:

: 20850-49-1
2-(3,4-dimethoxyphenyl)-3-methylbutyronitrile

: 251317-73-4
5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / LDA / tetrahydrofuran; hexane / -50 - 20 °C

2: 75 percent / LiAlH₄; AlCl₃ / diethyl ether / 16 h / 20 °C

3: 81 percent / Et₃N / tetrahydrofuran / 16 h / 20 °C

With lithium aluminium tetrahydride; aluminium trichloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; hexane; 1: Substitution / 2: Reduction / 3: Acylation;
DOI:10.1016/S0968-0896(99)00104-2

Reference yield:

: 36770-70-4
2-(3,4-dimethoxyphenyl)-5-hydroxy-2-(methylethyl)pentanenitrile

: 251317-73-4
5-(t-butoxycarbonyl)amino-4-(3,4-dimethoxyphenyl)-4-isopropyl-1-pentanol

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / LiAlH₄; AlCl₃ / diethyl ether / 16 h / 20 °C

2: 81 percent / Et₃N / tetrahydrofuran / 16 h / 20 °C

With lithium aluminium tetrahydride; aluminium trichloride; triethylamine; In tetrahydrofuran; diethyl ether; 1: Reduction / 2: Acylation;
DOI:10.1016/S0968-0896(99)00104-2