5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine

Base Information

Chemical Name:5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine
CAS No.:120232-06-6
Molecular Formula:C₂₃H₃₂N₂O₆SSi
Molecular Weight:492.668
Hs Code.:

Synonyms:5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine

Suppliers and Price of 5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine

There total 3 articles about 5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 40733-28-6
5'-tert-butyldimethylsilyloxy-2'-deoxythymidine

: 1005-56-7
phenylcarbonochloridothioate

: 120232-06-6
5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jo00272a062

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 120232-06-6
5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: Imidazole / dimethylformamide / 25 °C

2: Dimethylaminopyridine / CH₂Cl₂ / 25 °C

With 1H-imidazole; dmap; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94577-5

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 120232-06-6
5'-O-<(1,1-Dimethylethyl)-dimethylsilyl>-3'-O-(phenoxythioxomethyl)thymidine

Guidance literature:: Multi-step reaction with 2 steps

1: Imidazole / dimethylformamide / 25 °C

2: Dimethylaminopyridine / CH₂Cl₂ / 25 °C

With 1H-imidazole; dmap; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)94577-5