Technology Process of (R)-2-[1-(furan-3-yl)-1-phenylethyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
There total 2 articles about (R)-2-[1-(furan-3-yl)-1-phenylethyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-(-)-1-phenylethyl N,N-diisopropylcarbamate;
With
sec.-butyllithium;
In
diethyl ether; hexane; cyclohexane;
at -78 - -70 ℃;
for 0.25h;
Inert atmosphere;
3-furylboronic acid pinacol ester;
In
diethyl ether; hexane; cyclohexane;
at -78 ℃;
for 1h;
Inert atmosphere;
With
magnesium bromide;
In
methanol; diethyl ether; hexane; cyclohexane;
for 16h;
Reflux;
Inert atmosphere;
DOI:10.1002/anie.201402995
- Guidance literature:
-
(S)-N,N-diisopropyl O-[1-(4-methoxyphenyl)]ethyl carbamate;
With
sec.-butyllithium;
In
diethyl ether; hexane; cyclohexane;
at -75 - -70 ℃;
for 0.416667h;
Inert atmosphere;
3-furylboronic acid pinacol ester;
In
diethyl ether; hexane; cyclohexane;
at -70 - 25 ℃;
for 4.75h;
Inert atmosphere;
DOI:10.1016/j.tet.2009.10.002
- Guidance literature:
-
(R)-2-[1-(furan-3-yl)-1-phenylethyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; benzaldehyde;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 16h;
Inert atmosphere;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; water;
at 20 ℃;
for 1h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/anie.201402995
