N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide

Base Information

• Chemical Name: N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide
• CAS No.: 934421-22-4
• Molecular Formula: C₂₅H₃₂N₄O₇S
• Molecular Weight: 532.618
• Mol file: 934421-22-4.mol

Synonyms:N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide

Chemical Property of N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide

There total 2 articles about N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

Cyclohexyl isocyanide (931-53-3) + N-[(o-nitrophenyl)sulfonyl]-β-alanine (90558-39-7) + (E)-2-(benzylideneamino)ethanol (124948-51-2) → N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide (934421-22-4)

Guidance literature:

With 3 A molecular sieve; In methanol; at 20 ℃; for 24h;

DOI:10.1021/jo062626z

Reference yield:

benzaldehyde (100-52-7) → N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide (934421-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: molecular sieves 4 Angstroem / diethyl ether / 1 h / 20 °C

2: 79 percent / molecular sieves 3 Angstroem / methanol / 24 h / 20 °C

With 3 A molecular sieve; 4 A molecular sieve; In methanol; diethyl ether; 2: Ugi reaction;

DOI:10.1021/jo062626z

Reference yield: 41.0%

N-(cyclohexylcarbamoyl-phenyl-methyl)-N-(2-hydroxy-ethyl)-3-(2-nitro-benzenesulfonylamino)-propionamide (934421-22-4) → N-[3-(4-cyclohexyl-3-oxo-2-phenyl-piperazin-1-yl)-3-oxo-propyl]-2-nitro-benzenesulfonamide + N-cyclohexyl-2-[4-(2-nitro-benzenesulfonyl)-7-oxo-[1,4]diazepan-1-yl]-2-phenyl-acetamide

Guidance literature:

With N,N`-sulfuryldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1021/jo062626z

upstream raw materials:

Cyclohexyl isocyanide

N-[(o-nitrophenyl)sulfonyl]-β-alanine

(E)-2-(benzylideneamino)ethanol

benzaldehyde