phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate

Base Information

Chemical Name:phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate
CAS No.:1312592-79-2
Molecular Formula:C₂₉H₃₀ClN₃O₅S₂
Molecular Weight:600.159
Hs Code.:

Synonyms:phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate

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Chemical Property of phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate

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Technology Process of phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate

There total 6 articles about phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 287953-54-2
4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester

: 1312594-09-4
2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-amine

: 1312592-79-2
phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate

Guidance literature:: 2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; for 0.75h; Cooling with ice;

4-(chlorosulfonyl)piperidine-1-carboxylic acid benzyl ester; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1312592-79-2
phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran / 3 h / Cooling with ice

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

2.2: 1 h / -78 °C

3.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 12 h / 70 °C / Inert atmosphere

4.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 16 h / 35 °C

5.1: tin(IV) chloride / toluene / 0.33 h / 20 - 150 °C / microwave irradiation

5.2: 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / Cooling with ice

6.2: 16 h / 20 °C

With oxalyl dichloride; water; tin(IV) chloride; sodium hydrogencarbonate; sulfur; acetic acid; dimethyl sulfoxide; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;

Reference yield:

: 37951-49-8
1-(3-methoxyphenyl)propan-1-one

: 1312592-79-2
phenylmethyl 4-chloro-4-[({2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}amino)sulfonyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 12 h / 70 °C / Inert atmosphere

2.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 16 h / 35 °C

3.1: tin(IV) chloride / toluene / 0.33 h / 20 - 150 °C / microwave irradiation

3.2: 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / Cooling with ice

4.2: 16 h / 20 °C

With water; tin(IV) chloride; sodium hydrogencarbonate; sulfur; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; lithium hexamethyldisilazane; In tetrahydrofuran; toluene;