(2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol

Base Information

Chemical Name:(2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol
CAS No.:117781-09-6
Molecular Formula:C13H19 N O4
Molecular Weight:253.2943
Hs Code.:

Synonyms:3,4-Pyrrolidinediol,2-(1,2-dihydroxyethyl)-1-(phenylmethyl)-, [2R-[2a(S*),3a,4b]]-;N-Benzyl-1,4-dideoxy-1,4-imino-D-glucitol

Suppliers and Price of (2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol

Chemical Property:

Vapor Pressure:2.07E-10mmHg at 25°C
Boiling Point:489.8°Cat760mmHg
Flash Point:289.9°C
Density:1.386g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol

There total 7 articles about (2R,3S,4S)-1-benzyl-2-[(1R)-1,2-dihydroxyethyl]pyrrolidine-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3287-99-8,39110-74-2,108321-65-9
benzylamine hydrochloride

: 55908-15-1
D-xylo-hexos-4-ulose

: 1207673-22-0
(2S,3S,4S)-1-benzyl-2-((S)-1,2-dihydroxyethyl)pyrrolidine-3,4-diol

: 117781-09-6
N-benzyl-1,4-dideoxy-1,4-imino-D-glucitol

Guidance literature:: benzylamine hydrochloride; D-xylo-hexos-4-ulose; With acetic acid; In methanol; at 20 ℃; for 0.0833333h;

With sodium cyanoborohydride; In methanol; at 60 ℃; for 48h; stereoselective reaction;
DOI:10.1016/j.bioorg.2019.103298

Reference yield:

: 56710-46-4,67321-94-2,69602-93-3,94697-68-4,100227-29-0,102355-63-5,121357-95-7
5,6-O-isopropylidene-D-galactonic acid γ-lactone

: 117781-09-6
N-benzyl-1,4-dideoxy-1,4-imino-D-glucitol

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / imidazole / dimethylformamide / 48 h / Ambient temperature

2: 96 percent / lithium borohydride / tetrahydrofuran / 6 h / Ambient temperature

3: 53 percent / 4,4-dimethylaminopyridine / pyridine / 2 h / 0 °C

4: 92 percent / 60 h / 80 - 90 °C

5: 50percent aq. trifluoroacetic acid / 18 h / 50 °C

With 1H-imidazole; lithium borohydride; trifluoroacetic acid; dmap; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)81716-6

Reference yield:

: 117781-08-5
2,3-bis-(O-tert-butyldimethylsilyl)-5,6-O-isopropylidene-D-galactitol

: 117781-09-6
N-benzyl-1,4-dideoxy-1,4-imino-D-glucitol

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / 4,4-dimethylaminopyridine / pyridine / 2 h / 0 °C

2: 92 percent / 60 h / 80 - 90 °C

3: 50percent aq. trifluoroacetic acid / 18 h / 50 °C

With trifluoroacetic acid; dmap; In pyridine;
DOI:10.1016/S0040-4020(01)81716-6