Chemical Property of Nitrefazole
Chemical Property:
- Vapor Pressure:1.48E-09mmHg at 25°C
- Melting Point:185-187°
- Boiling Point:484.9°C at 760 mmHg
- Flash Point:247.1°C
- PSA：109.46000
- Density:1.53g/cm3
- LogP:3.04350
- Storage Temp.:Refrigerator
- Solubility.:Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
- XLogP3:2.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:1
- Exact Mass:248.05455475
- Heavy Atom Count:18
- Complexity:332
- Purity/Quality:
-
98%Min *data from raw suppliers
Nitrefazole *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1=NC(=CN1C2=CC=C(C=C2)[N+](=O)[O-])[N+](=O)[O-]
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Description
Nitrefazole is an inhibitor of aldehyde dehydrogenase useful in the management of
alcoholism. Cited advantages over disulfiram include longer duration of action,
higher specificity (no inhibition of dopamine β-hydroxylase) and fewer side
effects. It is generally recognized that the efficacy of such agents with respect
to permanent abstinence is low. However, temporary abstinence and/or
controlled drinking may facilitate supportive psychotherapy and/or delay the
onset of severe alcoholic diseases.
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Uses
Nitrefazole is a nitroimidazole derivative with the ability to inhibit aldehyde dehydrogenase, and enzyme crucial to the metabolism of alcohol. 1-(4-NITROPHENYL)-2-METHYL-4-NITROIMIDAZOLE is suitable for aldehyde dehydrogenase (ALDH) related research.
