73225-15-7

Basic information

• Product Name: 2-METHYL-1-(4-NITROPHENYL)-1H-IMIDAZOLE
• Synonyms: 2-METHYL-1-(4-NITROPHENYL)-1H-IMIDAZOLE;2-Methyl-1-(4-nitrophenyl)-1H-imidazole95%;1-(4-nitrophenyl)-2-Methylimidazole
• CAS NO: 73225-15-7
• Molecular Formula: C₁₀H₉N₃O₂
• Molecular Weight: 203.2
• Product Categories: API intermediates
• Mol File: 73225-15-7.mol
• Article Data: 26

Chemical Properties

• Melting Point: 138-139 °C
• Boiling Point: 396.522 °C at 760 mmHg
• Flash Point: 193.61 °C
• Appearance: /
• Density: 1.298 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 6.17±0.10(Predicted)
• CAS DataBase Reference: 2-METHYL-1-(4-NITROPHENYL)-1H-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-1-(4-NITROPHENYL)-1H-IMIDAZOLE(73225-15-7)
• EPA Substance Registry System: 2-METHYL-1-(4-NITROPHENYL)-1H-IMIDAZOLE(73225-15-7)

Safety Data

• Hazardous Substances Data: 73225-15-7(Hazardous Substances Data)

Usage

General Description

2-Methyl-1-(4-nitrophenyl)-1H-imidazole is a chemical compound with the molecular formula C10H8N4O2. It is an imidazole derivative with a substituted nitrophenyl group. 2-METHYL-1-(4-NITROPHENYL)-1H-IMIDAZOLE is often used in research and pharmaceutical applications due to its potential biological activity. It has been studied for its potential as an anti-inflammatory and anticancer agent, and has also been investigated for its antimicrobial properties. Additionally, it has been studied for its potential use in the development of new drugs and pharmaceutical products. Overall, 2-methyl-1-(4-nitrophenyl)-1H-imidazole is a compound with diverse potential applications in the fields of medicine and research.

Upstream product

• 693-98-1 2-methylimidazole 
• 586-78-7 para-nitrophenyl bromide 
• 24067-17-2 4-nitrophenylboronic acid 
• 636-98-6 p-nitrobenzene iodide 
• 100-00-5 4-chlorobenzonitrile 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 1312098-88-6 2-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazole 
• 1312099-59-4 1-(4-bromophenyl)-2-methyl-1H-imidazole 
• 189298-29-1 [4-(2-Methyl-imidazol-1-yl)-phenyl]-hydrazine 
• 74852-81-6 4-(2-methyl-1H-imidazol-1-yl)benzenamine 
• 21722-04-3 1-(p-nitrophenyl)-2-methyl-5-nitroimidazole 
• 21721-92-6 Nitrefazole 

Relevant articles and documents

N-Heterocyclic Carbene Copper(I) Complex Catalyzed Coupling of (Hetero)aryl Chlorides and Nitrogen Heterocycles: Highly Efficient Catalytic System

A highly efficient catalytic system for the N-arylation reactions of (hetero)aryl chlorides and nitrogen heterocycles with a copper(I) complex containing a 1,10-phenanthroline analogue N-heterocyclic carbene (NHC) has been reported. The complex was characterized by 1H NMR and 13C NMR spectroscopy and elemental analysis, and its structure was determined by single-crystal X-ray diffraction. The NHC-copper(I) complex was employed as pre-catalyst for Ullmann type N-arylation reactions of (hetero)aryl chlorides with various azoles. A variety of hindered and functionalized azoles and (hetero)aryl chlorides were transformed in good to excellent yields.

α-d-Galacturonic Acid as Natural Ligand for Selective Copper-Catalyzed N-Arylation of N-Containing Heterocycles

The first application of α-d-galacturonic acid hydrate (GalA) is reported here, as a potential O-donor ligand. The C-N couplings of N-heterocycles with aryl halides or arylboronic acids could be readily conducted and exhibited good functional group tolerance with characters of selectivity. These N-Arylazoles allow rapid access to several pharmaceutical intermediates and can be easily transformed into a variety of other interesting scaffolds as well.

N-ARYLATED ANALOGUES AND USES THEREOF

The present invention provides novel compounds of Formula (I′) and (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Als