4-[2-(4-Fluorophenoxy)ethyl]-1,3-thiazol-2-amine

Base Information

Chemical Name:4-[2-(4-Fluorophenoxy)ethyl]-1,3-thiazol-2-amine
CAS No.:890093-35-3
Molecular Formula:C₁₁H₁₁FN₂OS
Molecular Weight:238.286
Hs Code.:
DSSTox Substance ID:DTXSID401327928
ChEMBL ID:CHEMBL1584340
Mol file:890093-35-3.mol

Synonyms:890093-35-3;4-[2-(4-fluorophenoxy)ethyl]-1,3-thiazol-2-amine;MLS000678448;4-[2-(4-Fluoro-phenoxy)-ethyl]-thiazol-2-ylamine;SMR000323919;SCHEMBL2658289;CHEMBL1584340;BDBM55786;cid_2050022;TWNHPZYHAHMIPB-UHFFFAOYSA-N;DTXSID401327928;HMS1655N13;HMS2705B18;AKOS002286730;4-(2-(4-fluorophenoxy)ethyl)thiazol-2-amine;4-[2-(4-fluorophenoxy)ethyl]-2-thiazolamine;[4-[2-(4-fluorophenoxy)ethyl]thiazol-2-yl]amine;4-[2-(4-fluoranylphenoxy)ethyl]-1,3-thiazol-2-amine;F1924-0016;4-[2-(4-fluorophenoxy)ethyl]-1,3-thiazol-2-amine, AldrichCPR

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2-(4-Fluorophenoxy)ethyl]-1,3-thiazol-2-amine

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:238.05761231
Heavy Atom Count:16
Complexity:212

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1OCCC2=CSC(=N2)N)F

Technology Process of 4-[2-(4-Fluorophenoxy)ethyl]-1,3-thiazol-2-amine

There total 4 articles about 4-[2-(4-Fluorophenoxy)ethyl]-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1052722-18-5
{4-[2-(4-fluoro-phenoxy)-ethyl]-thiazol-2-yl}-carbamic acid tert-butyl ester

: 890093-35-3
4-[2-(4-fluoro-phenoxy)-ethyl]-thiazol-2-ylamine

Guidance literature:: {4-[2-(4-fluoro-phenoxy)-ethyl]-thiazol-2-yl}-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 147284-02-4
tert-butyl 4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate

: 890093-35-3
4-[2-(4-fluoro-phenoxy)-ethyl]-thiazol-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 4.17 - 4.25 h / 20 °C

2: potassium carbonate / toluene / 18 h / 80 °C

3: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

With potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; toluene;

Reference yield:

: 376636-17-8
2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)ethyl methanesulfonate

: 890093-35-3
4-[2-(4-fluoro-phenoxy)-ethyl]-thiazol-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / toluene / 18 h / 80 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 0 - 20 °C

With potassium carbonate; trifluoroacetic acid; In dichloromethane; toluene;