Carbamic acid, [4-(2-hydroxyethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

Chemical Name:Carbamic acid, [4-(2-hydroxyethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)
CAS No.:147284-02-4
Molecular Formula:C10H16 N2 O3 S
Molecular Weight:244.315
Hs Code.:
Mol file:147284-02-4.mol

Synonyms:Carbamicacid, [4-(2-hydroxyethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI); tert-Butyl4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate; tert-Butyl[4-(2-hydroxyethyl)thiazol-2-yl]carbamate

Suppliers and Price of Carbamic acid, [4-(2-hydroxyethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Carbamic acid, [4-(2-hydroxyethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

PKA:5.16±0.70(Predicted)
PSA：99.69000
Density:1.275±0.06 g/cm3(Predicted)
LogP:2.09790

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [4-(2-hydroxyethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI)

There total 5 articles about Carbamic acid, [4-(2-hydroxyethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 82548-78-5
ethyl {2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}acetate

: 147284-02-4
tert-butyl 4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate

Guidance literature:: ethyl {2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}acetate; With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 16h;

In methanol; for 1h; Reflux;

Reference yield:

: 53266-94-7
ethyl 2-amino-1,3-thiazol-4-acetate

: 147284-02-4
tert-butyl 4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / tetrahydrofuran / 18 h / 0 - 20 °C

2: sodium tetrahydroborate / ethanol / 18 h / 0 - 20 °C

With dmap; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 147284-02-4
tert-butyl 4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 20 °C

2.1: lithium borohydride / tetrahydrofuran / 16 h / 20 °C

2.2: 1 h / Reflux

With dmap; lithium borohydride; In tetrahydrofuran; dichloromethane;