3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester

Base Information

Chemical Name:3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester
CAS No.:136060-96-3
Molecular Formula:C₁₅H₁₅F₃O₃
Molecular Weight:300.278
Hs Code.:

Synonyms:3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester

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Chemical Property of 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester

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Technology Process of 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester

There total 4 articles about 3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 20445-31-2,56135-03-6,81655-41-6,17257-71-5
MTPA

: 139242-82-3
(S)-(+)-(methylenecyclopropyl)carbinol

: 136060-96-3
3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jo00034a050

Reference yield:

: 139242-75-4,139344-59-5
(2S)-1-(tert-Butyldimethylsiloxy)-4-(phenylsulfonyl)-5-(trimethylsilyl)-2-pentanol

: 136060-96-3
3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 79 percent / n-butyllithium, diisopropylamine / tetrahydrofuran; hexane / a.) -78 deg C to r.t., b.) r.t., 3 h

3: 35 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / Heating

4: 83 percent / 1,3-dicyclohexylcarbodiimide (DCC), DMAP / CH₂Cl₂ / 5 h / Ambient temperature

With dmap; n-butyllithium; tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo00034a050

Reference yield:

: 139242-79-8,139344-63-1
(2R)-2-<(tert-Butyldimethylsiloxy)methyl>-1-(phenylsulfonyl)-1-<(trimethylsilyl)methyl>cyclopropane

: 136060-96-3
3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2-methylene-cyclopropylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 35 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 0.5 h / Heating

2: 83 percent / 1,3-dicyclohexylcarbodiimide (DCC), DMAP / CH₂Cl₂ / 5 h / Ambient temperature

With dmap; tetrabutyl ammonium fluoride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00034a050