3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid

Base Information

Chemical Name:3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid
CAS No.:632624-21-6
Molecular Formula:C₂₅H₁₉BrClFN₂O₃
Molecular Weight:529.793
Hs Code.:

Synonyms:3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid

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Chemical Property of 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid

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Technology Process of 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid

There total 5 articles about 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid methyl ester

: 632624-21-6
3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid

Guidance literature:: With sodium hydroxide; water; In ethanol; at 120 ℃; for 0.0833333h; Microwave irradiation;

Reference yield:

: 632627-47-5
5-chloro-2-(4-bromo-2-fluorobenzyloxy)-benzaldehyde

: 632624-21-6
3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / ethanol / 7 h / Heating / reflux

2: toluene-4-sulfonic acid / acetonitrile / 0.17 h / 160 °C / Microwave irradiation

3: sodium hydroxide; water / ethanol / 0.08 h / 120 °C / Microwave irradiation

With sodium hydroxide; water; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; toluene-4-sulfonic acid; triethylamine; In ethanol; acetonitrile;

Reference yield:

: 632627-48-6
1-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-pentane-1,4-dione

: 632624-21-6
3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-5-aminobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / acetonitrile / 0.17 h / 160 °C / Microwave irradiation

2: sodium hydroxide; water / ethanol / 0.08 h / 120 °C / Microwave irradiation

With sodium hydroxide; water; toluene-4-sulfonic acid; In ethanol; acetonitrile;