(1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one

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Chemical Name:(1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one
CAS No.:197647-46-4
Molecular Formula:C₃₀H₄₆O₄
Molecular Weight:470.693
Hs Code.:

Synonyms:(1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one

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Chemical Property of (1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one

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Technology Process of (1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one

There total 8 articles about (1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 197647-38-4
(1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol

: 197647-46-4
(1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one

Guidance literature:: With dipyridinium dichromate; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 197647-46-4
(1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 21 h / Heating

2: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

3: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

4: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

5: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

6: 80 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

7: 75 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / 60 °C

8: 74 percent / pyridinium dichromate / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; lithium aluminium tetrahydride; dipyridinium dichromate; 18-crown-6 ether; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 197647-61-3
20-methyl-de-A,B-pregnan-(8S)-ol

: 197647-46-4
(1R,3aR,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

2: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

3: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

4: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

5: 80 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

6: 75 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / 60 °C

7: 74 percent / pyridinium dichromate / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; dipyridinium dichromate; 18-crown-6 ether; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8