(1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol

Base Information

Chemical Name:(1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol
CAS No.:197647-38-4
Molecular Formula:C₃₀H₄₈O₄
Molecular Weight:472.709
Hs Code.:

Synonyms:(1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol

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Chemical Property of (1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol

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Technology Process of (1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol

There total 7 articles about (1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 197647-31-7
tert-Butyl-((1R,3aR,4R,7aS)-7a-{3-[1-ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-yloxy)-dimethyl-silane

: 197647-38-4
(1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 60 ℃; for 3h;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 197647-38-4
(1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 21 h / Heating

2: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

3: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

4: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

5: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

6: 80 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

7: 75 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / 60 °C

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; lithium aluminium tetrahydride; 18-crown-6 ether; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 197647-61-3
20-methyl-de-A,B-pregnan-(8S)-ol

: 197647-38-4
(1R,3aR,4R,7aS)-7a-{3-[1-Ethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-benzyloxymethyl}-1-isopropyl-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

2: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

3: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

4: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

5: 80 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

6: 75 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / 60 °C

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; 18-crown-6 ether; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8