trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate

Base Information

Chemical Name:trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate
CAS No.:1357001-82-1
Molecular Formula:C₆H₈O₇*C₃₃H₃₄FN₃O
Molecular Weight:699.776
Hs Code.:

trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate

Synonyms:trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate

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Chemical Property of trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate

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Technology Process of trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate

There total 2 articles about trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1357001-81-0
cis-(E)-4-(3-fluorophenyl)-2’,3’,4’,9’-tetrahydro-N,N-dimethyl-2’-(1-oxo-3-phenyl-2-propenyl)spiro[cyclohexane-1,1’[1H]-pyrido[3,4-b]indol]-4-amine

: 77-92-9,906507-37-7
citric acid

: 1357001-82-1
trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate

Guidance literature:: In diethyl ether; ethanol; at 20 - 80 ℃; for 19.5h;

Reference yield:

: 1002916-54-2
[8-(3-Fluoro-phenyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-dimethyl-amine hydrochloride

: 1357001-82-1
trans-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(3-fluorophenyl)-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine citrate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: methanol / 24 h / Inert atmosphere

2.2: 2 h / 20 °C

3.1: diethyl ether; ethanol / 19.5 h / 20 - 80 °C

With hydrogenchloride; water; In methanol; diethyl ether; ethanol;