Technology Process of C20H34IO3SiN3
There total 3 articles about C20H34IO3SiN3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-iodo-2,3-diisopropoxy-5-vinylbenzene;
With
AD-mix-α;
In
water; tert-butyl alcohol;
at 25 ℃;
for 6h;
tert-butyldimethylsilyl chloride;
With
1H-imidazole;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 5h;
With
di-isopropyl azodicarboxylate; diphenylphosphoranyl azide; triphenylphosphine;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
Further stages. Title compound not separated from byproducts.;
DOI:10.1021/ol070889p
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -20 °C
1.2: 84 percent / tetrahydrofuran; hexane / 2.5 h / 20 °C
2.1: AD-mix-α / 2-methyl-propan-2-ol; H2O / 6 h / 25 °C
2.2: imidazole / dimethylformamide / 5 h / 0 °C
2.3: triphenylphosphine; diisopropyl azodicarboxylate; diphenylphosphoryl azide / tetrahydrofuran / 2 h / 0 °C
With
AD-mix-α; n-butyllithium;
In
tetrahydrofuran; hexane; water; tert-butyl alcohol;
2.1: Sharpless asymmetric dihydroxylation / 2.3: Mitsunobu reaction;
DOI:10.1021/ol070889p
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 91 percent / K2CO3 / dimethylformamide / 120 h / 55 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 0.75 h / -20 °C
2.2: 84 percent / tetrahydrofuran; hexane / 2.5 h / 20 °C
3.1: AD-mix-α / 2-methyl-propan-2-ol; H2O / 6 h / 25 °C
3.2: imidazole / dimethylformamide / 5 h / 0 °C
3.3: triphenylphosphine; diisopropyl azodicarboxylate; diphenylphosphoryl azide / tetrahydrofuran / 2 h / 0 °C
With
AD-mix-α; n-butyllithium; potassium carbonate;
In
tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
3.1: Sharpless asymmetric dihydroxylation / 3.3: Mitsunobu reaction;
DOI:10.1021/ol070889p
