bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate

Base Information

Chemical Name:bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate
CAS No.:1447464-03-0
Molecular Formula:C₂₄H₂₇N₂O₉P
Molecular Weight:518.46
Hs Code.:

Synonyms:bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate

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Chemical Property of bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate

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Technology Process of bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate

There total 7 articles about bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1447464-00-7
bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate

: 1447464-03-0
bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate

Guidance literature:: With trifluoroacetic acid; In chloroform; at 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1002/anie.201301092

Reference yield:

: 73627-97-1
(R)-3-phenyl-3-hydroxypropanenitrile

: 1447464-03-0
bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2.1: 5-(4-fluorophenyl)-1H-1,2,3,4-tetrazole / acetonitrile / 4.5 h / 20 °C / Inert atmosphere

2.2: 0.33 h / 0 °C / Inert atmosphere

3.1: trifluoroacetic acid / chloroform / 2.5 h / 20 °C / Inert atmosphere

With triethylamine; 5-(4-fluorophenyl)-1H-1,2,3,4-tetrazole; trifluoroacetic acid; In tetrahydrofuran; chloroform; acetonitrile;
DOI:10.1002/anie.201301092

Reference yield:

: 1447463-96-8
bis((R)-2-cyano-1-phenylethyl) diisopropylphosphoramidite

: 1447464-03-0
bis((R)-2-cyano-1-phenylethyl) ((1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl)phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 5-(4-fluorophenyl)-1H-1,2,3,4-tetrazole / acetonitrile / 4.5 h / 20 °C / Inert atmosphere

1.2: 0.33 h / 0 °C / Inert atmosphere

2.1: trifluoroacetic acid / chloroform / 2.5 h / 20 °C / Inert atmosphere

With 5-(4-fluorophenyl)-1H-1,2,3,4-tetrazole; trifluoroacetic acid; In chloroform; acetonitrile;
DOI:10.1002/anie.201301092