bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate

Base Information

Chemical Name:bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate
CAS No.:1447464-00-7
Molecular Formula:C₅₆H₅₉N₂O₁₃P
Molecular Weight:999.064
Hs Code.:

Synonyms:bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate

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Chemical Property of bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate

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Technology Process of bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate

There total 8 articles about bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1447463-96-8
bis((R)-2-cyano-1-phenylethyl) diisopropylphosphoramidite

: 1447463-99-1
(1R,2r,3S,4R,5r,6S)-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexane-1,3-diol

: 1447464-00-7
bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate

: 1447464-01-8
C₅₆H₅₉N₂O₁₃P

Guidance literature:: bis((R)-2-cyano-1-phenylethyl) diisopropylphosphoramidite; (1R,2r,3S,4R,5r,6S)-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexane-1,3-diol; With 5-(4-fluorophenyl)-1H-1,2,3,4-tetrazole; In acetonitrile; at 20 ℃; for 4.5h; Inert atmosphere;

With 3-chloro-benzenecarboperoxoic acid; In water; acetonitrile; at 0 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1002/anie.201301092

Reference yield:

: C₅₆H₅₉N₂O₁₂P

: 1447464-00-7
bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate

: C₅₆H₅₉N₂O₁₃P

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1016/j.bmc.2015.03.023

Reference yield:

: 73627-97-1
(R)-3-phenyl-3-hydroxypropanenitrile

: 1447464-00-7
bis((R)-2-cyano-1-phenylethyl) ((1R,2R,3R,4R,5S,6R)-3-hydroxy-2,4,5,6-tetrakis((4-methoxybenzyl)oxy)cyclohexyl) phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 72 h / 20 °C / Inert atmosphere

2.1: 5-(4-fluorophenyl)-1H-1,2,3,4-tetrazole / acetonitrile / 4.5 h / 20 °C / Inert atmosphere

2.2: 0.33 h / 0 °C / Inert atmosphere

With triethylamine; 5-(4-fluorophenyl)-1H-1,2,3,4-tetrazole; In tetrahydrofuran; acetonitrile;
DOI:10.1002/anie.201301092