1-methyl-3-propyl-1H-indole

Base Information

• Chemical Name: 1-methyl-3-propyl-1H-indole
• CAS No.: 1170697-31-0
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.258
• Mol file: 1170697-31-0.mol

Synonyms:1-methyl-3-propyl-1H-indole

Chemical Property of 1-methyl-3-propyl-1H-indole

Chemical Property:

Purity/Quality:

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Technology Process of 1-methyl-3-propyl-1H-indole

There total 1 articles about 1-methyl-3-propyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-propylzinc bromide lithium chloride + 3-bromo-1-methyl-1H-indole (81471-20-7) → 1-methyl-3-propyl-1H-indole (1170697-31-0) + 3-isopropyl-1-methyl-1H-indole (93549-88-3)

Guidance literature:

With dichloro[1,3-bis(2,6-di-4-heptylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II); In tetrahydrofuran; toluene; at 0 - 23 ℃; for 1.08333h; Reagent/catalyst; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201503941

Reference yield: 98.0%

2-(hydroxy(phenyl)methyl)phenol (40473-50-5) + 1-methyl-3-propyl-1H-indole (1170697-31-0) → (S)-2-((1-methyl-3-propyl-1H-indol-2-yl)(phenyl)methyl)phenol

Guidance literature:

2-(hydroxy(phenyl)methyl)phenol; With C₄₃H₆₂Br₂N₄O₄; lithium bromide; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; at 35 ℃; for 0.5h; Molecular sieve; Inert atmosphere;

1-methyl-3-propyl-1H-indole; In tetrahydrofuran; at 40 ℃; for 72h; enantioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1002/chem.201604088

Reference yield: 92.0%

1-methyl-3-propyl-1H-indole (1170697-31-0) + 1-p-toluenesulfonyl-4-ethynyl-1,4-dihydro-2H-benzo[d][1,3]-azahexan-2-one → 11-ethynyl-6-methyl-10b-propyl-5-tosyl-5a,6,10b,11-tetrahydro-5H-indolo[2,3-b]quinoline

Guidance literature:

With copper(l) iodide; C₃₅H₃₀N₂O₂; N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 0.5h; diastereoselective reaction; Inert atmosphere; Green chemistry;

DOI:10.1021/acs.orglett.7b01903

upstream raw materials:

3-bromo-1-methyl-1H-indole