1H-Indole,1-methyl-3-(1-methylethyl)-(9CI)

Base Information

• Chemical Name: 1H-Indole,1-methyl-3-(1-methylethyl)-(9CI)
• CAS No.: 93549-88-3
• Molecular Formula: C12H15 N
• Molecular Weight: 173.258
• Mol file: 93549-88-3.mol

Synonyms:3-Isopropyl-1-methylindole

Chemical Property of 1H-Indole,1-methyl-3-(1-methylethyl)-(9CI)

Chemical Property:

• PSA: 4.93000
• LogP: 3.30170

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole,1-methyl-3-(1-methylethyl)-(9CI)

There total 9 articles about 1H-Indole,1-methyl-3-(1-methylethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-isopropyl indole (16886-00-3) + methyl iodide (74-88-4) → 3-isopropyl-1-methyl-1H-indole (93549-88-3)

Guidance literature:

With potassium tert-butylate; In benzene;

Reference yield: 85.0%

1-methylindole (603-76-9) + isopropyl alcohol (67-63-0,8013-70-5) → 3-isopropyl-1-methyl-1H-indole (93549-88-3)

Guidance literature:

With 2-Methoxyacetophenone; trifluorormethanesulfonic acid; In toluene; at 100 ℃; for 2h;

DOI:10.1021/jacs.5b10221

Reference yield:

indole (120-72-9) → 3-isopropyl-1-methyl-1H-indole (93549-88-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylsilane; trichloroacetic acid / toluene / 70 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h

2.2: 0 - 20 °C

With triethylsilane; sodium hydride; trichloroacetic acid; In N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1002/chem.201100283

upstream raw materials:

indole

dimethyl sulfate

isopropyl bromide

o-phenyl isopropyl ketone

Downstream raw materials:

((4aR,9aS)-4a-isopropyl-9-methyl-3-phenyl-4,4a,9,9a-tetrahydro-1H-pyridazino[3,4-b]indol-1-yl)(phenyl)methanone

C₁₉H₁₉F₂NO₂S

1-methyl-3-isopropyl-2-<(4-methoxyphenyl)sulfonyl>indole