methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

Base Information

Chemical Name:methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate
CAS No.:1185730-59-9
Molecular Formula:C₂₆H₂₉BrN₂O₇S
Molecular Weight:593.495
Hs Code.:

Synonyms:methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

Suppliers and Price of methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

There total 7 articles about methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 35444-44-1
methyl adipoyl chloride

: 1185730-58-8
8-bromo-2-(1-hydroxy-3-(methylamino)propyl)quinolin-7-yl benzenesulfonate

: 1185730-59-9
methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ja809933h

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1185730-59-9
methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14.16 h / 0 - 20 °C / Inert atmosphere

2: selenium(IV) oxide / 1,4-dioxane / 24 h / 80 °C / Inert atmosphere

3: water; indium; ammonium chloride / tetrahydrofuran / 3 h / Inert atmosphere

4: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 25 °C / Inert atmosphere

5: sodium tris(acetoxy)borohydride / acetic acid / methanol / 20 h / 25 °C / Inert atmosphere

6: dichloromethane / 6.08 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; selenium(IV) oxide; potassium osmate(VI) dihydrate; indium; sodium periodate; water; sodium tris(acetoxy)borohydride; ammonium chloride; N-ethyl-N,N-diisopropylamine; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 1185730-54-4
8-bromo-2-formylquinolin-7-yl benzenesulfonate

: 1185730-59-9
methyl 6-(((3-(8-bromo-7-(phenylsulfonyloxy)quinolin-2-yl)-3-hydroxypropyl)methyl)amino)-6-oxohexanoate

Guidance literature:: Multi-step reaction with 4 steps

1: water; indium; ammonium chloride / tetrahydrofuran / 3 h / Inert atmosphere

2: 2,6-dimethylpyridine; sodium periodate; potassium osmate(VI) dihydrate / 1,4-dioxane; water / 25 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / acetic acid / methanol / 20 h / 25 °C / Inert atmosphere

4: dichloromethane / 6.08 h / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; potassium osmate(VI) dihydrate; indium; sodium periodate; water; sodium tris(acetoxy)borohydride; ammonium chloride; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water;